(S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

Base Information

Chemical Name:(S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide
CAS No.:182268-05-9
Molecular Formula:C₂₇H₂₉N₃O₄
Molecular Weight:459.545
Hs Code.:

Synonyms:(S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

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Chemical Property of (S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

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Technology Process of (S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

There total 3 articles about (S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17186-53-7,92698-80-1
L-phenylalanine cyclohexylamide

: 182268-05-9
(S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / Et(i-Pr)2N / various solvent(s) / 32 h / 80 °C / in NMP

2: 1.) CF₃COOH 2.) SOCl₂ / 1.) CH₂Cl₂, r.t., 5 h 2.) CH₂Cl₂, r.t., 15 h

With thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In various solvent(s);
DOI:10.1002/hlca.19960790508

Reference yield:

: (4-Iodomethyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-acetic acid tert-butyl ester

: 182268-05-9
(S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / Et(i-Pr)2N / various solvent(s) / 32 h / 80 °C / in NMP

2: 1.) CF₃COOH 2.) SOCl₂ / 1.) CH₂Cl₂, r.t., 5 h 2.) CH₂Cl₂, r.t., 15 h

With thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In various solvent(s);
DOI:10.1002/hlca.19960790508

Reference yield:

: 182268-04-8
[(S)-4-((S)-1-Cyclohexylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-4,5-dihydro-oxazol-4-yl]-acetic acid tert-butyl ester

: 182268-05-9
(S)-N-Cyclohexyl-2-((S)-6,8-dioxo-2-phenyl-3-oxa-1,7-diaza-spiro[4.4]non-1-en-7-yl)-3-phenyl-propionamide

Guidance literature:: With thionyl chloride; trifluoroacetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂, r.t., 5 h 2.) CH₂Cl₂, r.t., 15 h;
DOI:10.1002/hlca.19960790508