N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride

Base Information

• Chemical Name: N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride
• CAS No.: 1269408-19-6
• Molecular Formula: C₁₆H₂₁N₅O₃*ClH
• Molecular Weight: 367.835

Synonyms:N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride

Chemical Property of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride

Chemical Property:

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Technology Process of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride

There total 4 articles about N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norvalinamide (1269406-76-9) → N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride (1269408-19-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 45 - 50 ℃; for 5h;

Reference yield:

2-fluoro-5-nitrobenzonitrile (17417-09-3) → N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride (1269408-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 5 h / 45 - 50 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate (1269406-69-0) → N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norvalinamide hydrochloride (1269408-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 45 - 50 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;

upstream raw materials:

2-fluoro-5-nitrobenzonitrile

1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate

2-[(3S)-3-amino-1-pyrrolidinyl]-5-nitrobenzonitrile hydrochloride

N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norvalinamide

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