(3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:(3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate
CAS No.:1394920-51-4
Molecular Formula:C₂₂H₂₃BrN₂O₅
Molecular Weight:475.339
Hs Code.:

Synonyms:(3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

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Chemical Property of (3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

Chemical Property:

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Technology Process of (3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

There total 2 articles about (3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3156-37-4
4-bromo-β-nitrostyrene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1169769-85-0
(3R)-3-[(1S)-1-(4-bromo-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1394920-51-4
(3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

: tert-butyl 3-[1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

Guidance literature:: With quinine; In chloroform; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2012.06.018

Reference yield:

: 3156-37-4,5153-71-9
(E)-1-bromo-4-(2-nitrovinyl)benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1169769-85-0
(3R)-3-[(1S)-1-(4-bromo-phenyl)-2-nitro-ethyl]-3-methyl-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1394920-51-4
(3S)-tert-butyl 3-[(1R)-1-(4-bromophenyl)-2-nitroethyl]-3-methyl-2-oxoindoline-1-carboxylate

: C₂₂H₂₃BrN₂O₅

Guidance literature:: With C₆₂H₆₈N₆NiO₄⁽²⁺⁾*2BF₄^(1-); In dichloromethane; at 20 ℃; for 20h; Overall yield = 66 %; Overall yield = 90 %Spectr.; stereoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.201502930