2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate
CAS No.:1361413-40-2
Molecular Formula:C₂HF₃O₂*C₃₀H₂₉N₃O₅S₂
Molecular Weight:689.733
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

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Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

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Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

There total 7 articles about 2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1361414-30-3
(2-amino-4-(3-morpholinophenyl)thiazol-5-yl)(phenyl)methanone

: 76-05-1
trifluoroacetic acid

: 1361413-40-2
2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

Guidance literature:: 2-[4-(ethanesulfonyl)phenyl]acetic acid; (2-amino-4-(3-morpholinophenyl)thiazol-5-yl)(phenyl)methanone; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 1361414-27-8
[2-(bis{[4-(methyloxy)phenyl]methyl}amino)-4-(3-bromophenyl)-1,3-thiazol-5-yl](phenyl)methanone

: 1361413-40-2
2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 3 h / 90 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium diacetate; In dichloromethane; toluene;

Reference yield:

: 1361414-25-6
N-[(bis{[4-(methyloxy)phenyl]methyl}amino)carbonothioyl]-3-bromobenzamide

: 1361413-40-2
2-[4-(ethylsulfonyl)phenyl]-N-[4-[3-(4-morpholinyl)phenyl]-5-(phenylcarbonyl)-1,3-thiazol-2-yl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 3 h / 90 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; toluene;