(4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

Base Information

Chemical Name:(4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride
CAS No.:934280-74-7
Molecular Formula:C₂₄H₂₂FN₅O*ClH
Molecular Weight:451.931
Hs Code.:

Synonyms:(4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

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Chemical Property of (4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

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Technology Process of (4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

There total 3 articles about (4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 893420-22-9
5-fluoro-4-(2-methyl-3-(propan-2-yl)-3H-imidazol-4-yl)pyrimidin-2-amine

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 934280-74-7
(4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

Guidance literature:: 5-fluoro-4-(2-methyl-3-(propan-2-yl)-3H-imidazol-4-yl)pyrimidin-2-amine; (4-bromophenyl)(phenyl)methanone; With sodium t-butanolate; palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 110 - 120 ℃; for 24h;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 862685-76-5
(2Z)-3-(dimethylamino)-2-fluoro-1-(1-isopropyl-2-methyl-1H-imidazol-5-yl)prop-2-en-1-one

: 934280-74-7
(4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / butan-1-ol / 0.17 h / 140 °C / Microwave irradiation

2: sodium t-butanolate / palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 110 - 120 °C

With sodium methylate; sodium t-butanolate; palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; butan-1-ol;

Reference yield:

: 862686-53-1
(2E)-3-(dimethylamino)-1-(1-isopropyl-2-methyl-1H-imidazol-5-yl) prop-2-en-1-one

: 934280-74-7
(4-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}phenyl)(phenyl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: Selectfluor / methanol / 3.42 h / -70 - 20 °C

2: sodium methylate / butan-1-ol / 0.17 h / 140 °C / Microwave irradiation

3: sodium t-butanolate / palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 24 h / 110 - 120 °C

With sodium methylate; Selectfluor; sodium t-butanolate; palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; methanol; butan-1-ol;