5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1429870-22-3
Molecular Formula:C₁₈H₁₇BrClF₂N₃O
Molecular Weight:444.706
Hs Code.:

Synonyms:5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Chemical Property of 5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of 5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 13 articles about 5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429869-80-6
{5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl}-carbamic acid tert-butyl ester

: 1429870-22-3
5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 50 ℃; for 2h;

Reference yield:

: 1262859-94-8
2-amino-2-(5-bromo-2-fluoro-phenyl)-propane-1,3-diol

: 1429870-22-3
5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / acetonitrile / 2 h / 35 °C

2.1: potassium tert-butylate; tert-butyl alcohol / 0.5 h / Reflux

3.1: diethylamino-sulfur trifluoride / tetrahydrofuran / 2 h

4.1: Lawessons reagent / tetrahydrofuran / 1 h / Reflux

5.1: ammonia / methanol / 15 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

7.1: sodium L-ascorbate; copper(l) iodide; sodium azide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / water; ethanol / 70 °C / Inert atmosphere

8.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol

9.1: magnesium sulfate / dichloromethane / 0.25 h / 100 °C

9.2: 5 h

10.1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 50 °C

With Lawessons reagent; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; hydrogenchloride; copper(l) iodide; sodium azide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; potassium tert-butylate; ammonia; hydrogen; magnesium sulfate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1262859-92-6
4-bromo-1-fluoro-2-nitromethyl-benzene

: 1429870-22-3
5-[5-(4-bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 12 steps

1.1: triethylamine / 1,4-dioxane / 3 h

2.1: acetic acid; zinc / 1 h / 40 °C

3.1: potassium carbonate / acetonitrile / 2 h / 35 °C

4.1: potassium tert-butylate; tert-butyl alcohol / 0.5 h / Reflux

5.1: diethylamino-sulfur trifluoride / tetrahydrofuran / 2 h

6.1: Lawessons reagent / tetrahydrofuran / 1 h / Reflux

7.1: ammonia / methanol / 15 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

9.1: sodium L-ascorbate; copper(l) iodide; sodium azide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / water; ethanol / 70 °C / Inert atmosphere

10.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol

11.1: magnesium sulfate / dichloromethane / 0.25 h / 100 °C

11.2: 5 h

12.1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 50 °C

With Lawessons reagent; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; hydrogenchloride; copper(l) iodide; sodium azide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; potassium tert-butylate; ammonia; hydrogen; magnesium sulfate; potassium carbonate; acetic acid; sodium L-ascorbate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; tert-butyl alcohol; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;