3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride

Base Information

Chemical Name:3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride
CAS No.:1221962-44-2
Molecular Formula:C₂₁H₂₃IN₂O₂*ClH
Molecular Weight:498.791
Hs Code.:

Synonyms:3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride

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Chemical Property of 3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride

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Technology Process of 3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride

There total 8 articles about 3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 21304-38-1
4-iodobenzene-1,2-diamine

: 185049-55-2
3-(4-tert-butylphenyl)glutaric anhydride

: 1221962-44-2
3-(4-t-butylphenyl)-4-(5-iodo-2-benzimidazolyl)butanoic acid hydrochloride

Guidance literature:: 4-iodobenzene-1,2-diamine; 3-(4-tert-butylphenyl)glutaric anhydride; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; for 1.5h; Reflux;
DOI:10.1021/jm2005892

Reference yield:

: 20691-72-9
4-iodo-2-nitroaniline

: 1221962-44-2
3-(4-t-butylphenyl)-4-(5-iodo-2-benzimidazolyl)butanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / ethanol / 2 h / 75 °C

2.1: dichloromethane / 1 h / 20 °C

2.2: 1.5 h / Reflux

With tin(II) chloride dihdyrate; In ethanol; dichloromethane;
DOI:10.1021/jm2005892

Reference yield:

: 20691-72-9
4-iodo-2-nitroaniline

: 1221962-44-2
3-(4-tert-butylphenyl)-4-(5-iodo-2-benzimidazolyl)-butanoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / ethanol / 2 h / 75 °C

2.1: dichloromethane / 1 h / 20 °C

2.2: 1.5 h / Reflux

With tin(II) chloride dihdyrate; In ethanol; dichloromethane;