tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Base Information

• Chemical Name: tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate
• CAS No.: 1197285-67-8
• Molecular Formula: C₃₉H₆₂N₆O₉
• Molecular Weight: 758.956
• Mol file: 1197285-67-8.mol

Synonyms:tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Chemical Property of tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

There total 1 articles about tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl (S)-4-methyl-2-((S)-pyrrolidine-2-carboxamido)pentanoate (61878-30-6) + (S)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoic acid (1197285-65-6) → tert-butyl (S)-2-((S)-1-((S)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate (1197285-66-7) + tert-butyl (S)-2-((S)-1-((R)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate (1197285-67-8)

Guidance literature:

With 2,3,5-trimethyl-pyridine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 4.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/jo902115s

upstream raw materials:

tert-butyl (S)-4-methyl-2-((S)-pyrrolidine-2-carboxamido)pentanoate

(S)-2-benzamido-6-(2,3-bis(tert-butoxycarbonyl)guanidino)hexanoic acid