(1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.0^2,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester

Base Information

• Chemical Name: (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.0^2,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester
• CAS No.: 72003-84-0
• Molecular Formula: C₃₀H₂₇NO₇
• Molecular Weight: 513.547

Synonyms:(1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.0^2,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester

Chemical Property of (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.0^2,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester

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Technology Process of (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.0^2,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester

There total 6 articles about (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.0^2,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-bis(methoxycarbonyl)-3,4-diphenylcyclopentadienone (16691-79-5) + N-ethoxycarbonylazepine (2955-79-5) → (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.02,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester (72003-84-0) + (1S,2S,5R,6R)-12-Oxo-3,4-diphenyl-11-aza-tricyclo[4.4.1.12,5]dodeca-3,7,9-triene-2,5,11-tricarboxylic acid 11-ethyl ester 2,5-dimethyl ester (72001-25-3)

Guidance literature:

In benzene; at 80 ℃; for 6h; Yield given. Yields of byproduct given;

DOI:10.1021/jo01310a037

Reference yield:

2,5-bis(methoxycarbonyl)-3,4-diphenylcyclopentadienone (16691-79-5) + N-ethoxycarbonylazepine (2955-79-5) → (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.02,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester (72003-84-0) + (1R,2S,5R,6S)-12-Oxo-3,4-diphenyl-11-aza-tricyclo[4.4.1.12,5]dodeca-3,7,9-triene-2,5,11-tricarboxylic acid 11-ethyl ester 2,5-dimethyl ester

Guidance literature:

In benzene; at 80 ℃; for 12h;

DOI:10.1016/S0040-4020(99)00259-8

Reference yield:

2,5-bis(methoxycarbonyl)-3,4-diphenylcyclopentadienone (16691-79-5) → (1R,2S,6R,7R)-3-Oxo-5,6-diphenyl-8-aza-tricyclo[5.3.2.02,6]dodeca-4,9,11-triene-2,4,8-tricarboxylic acid 8-ethyl ester 2,4-dimethyl ester (72003-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 16 h / Ambient temperature

2: ethanol / 72 h / 34.1 °C / rate constant at different temp, Ea, Δ S

In ethanol; benzene;

DOI:10.1021/jo01310a037

upstream raw materials:

(1R,2S,8R,9S)-12-Oxo-10,11-diphenyl-5-aza-tricyclo[7.2.1.0^2,8]dodeca-3,6,10-triene-1,5,9-tricarboxylic acid 5-ethyl ester 1,9-dimethyl ester

2,5-bis(methoxycarbonyl)-3,4-diphenylcyclopentadienone

N-ethoxycarbonylazepine

Downstream raw materials:

1,2-diphenyl-5,7-bis(methoxycarbonyl)-11-(ethoxycarbonyl)-11-azapentacyclo<5.5.0.0^2,5.0^3,12.0^4,8>dodeca-9-en-6-one

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