Technology Process of (1S,3aS,5R,7aR)-1-hydroxymethyl-5-phenyl-7a-methylperhydroinden-3a-ol
There total 11 articles about (1S,3aS,5R,7aR)-1-hydroxymethyl-5-phenyl-7a-methylperhydroinden-3a-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
for 2h;
DOI:10.1021/jm011001k
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 83 percent / oxalic acid / acetonitrile / 16 h
2.1: 77 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 2 h / Heating
3.1: BH3 / tetrahydrofuran / 1 h / 20 °C
3.2: 20 percent / NaBO3; aq. NaOH / 16 h / 20 °C
4.1: 68 percent / 1 N pTSA / acetonitrile; H2O / 16 h
5.1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C
6.1: 88 percent / H2; HClO4 / 5percent Pd/C / ethyl acetate / 2 h / atmospheric pressure
7.1: 48 percent / imidazole / dimethylformamide / 16 h / 20 °C
8.1: 100 percent / aq. HCl / dioxane / 2 h
With
1H-imidazole; hydrogenchloride; perchloric acid; borane; potassium tert-butylate; hydrogen; oxalic acid; toluene-4-sulfonic acid;
5percent Pd/C;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
2.1: Wittig reaction;
DOI:10.1021/jm011001k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C
2: 88 percent / H2; HClO4 / 5percent Pd/C / ethyl acetate / 2 h / atmospheric pressure
3: 48 percent / imidazole / dimethylformamide / 16 h / 20 °C
4: 100 percent / aq. HCl / dioxane / 2 h
With
1H-imidazole; hydrogenchloride; perchloric acid; hydrogen;
5percent Pd/C;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; cyclohexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm011001k