methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Base Information

Chemical Name:methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate
CAS No.:1384485-34-0
Molecular Formula:C₁₃H₁₂ClNO₃
Molecular Weight:265.696
Hs Code.:
Mol file:1384485-34-0.mol

Synonyms:methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Suppliers and Price of methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Chemical Property:

Purity/Quality:: >98% ^*data from raw suppliers

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Technology Process of methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

There total 6 articles about methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1384485-33-9
methyl 5-(4-(hydroxymethyl)phenyl)-3-methylisoxazole-4-carboxylate

: 1384485-34-0
methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Guidance literature:: With tetrachloromethane; triphenylphosphine; In dichloromethane; at 20 - 50 ℃; for 0.333333h;
DOI:10.1016/j.bmcl.2012.05.012

Reference yield:

: 18282-51-4
4-iodo-benzyl alcohol

: 1384485-34-0
methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1.75 h / 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 16 h / -78 - 35 °C

3.1: phenyl isocyanate; triethylamine / toluene / 4 h / 20 - 80 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 °C

5.1: tetrachloromethane; triphenylphosphine / dichloromethane / 0.33 h / 20 - 50 °C

With 1H-imidazole; tetrachloromethane; n-butyllithium; tetrabutyl ammonium fluoride; phenyl isocyanate; triethylamine; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 2.2: Negishi coupling reaction;
DOI:10.1016/j.bmcl.2012.05.012

Reference yield:

: 1383717-87-0
methyl 3-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-prop-2-ynoate

: 1384485-34-0
methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: phenyl isocyanate; triethylamine / toluene / 4 h / 20 - 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 °C

3: tetrachloromethane; triphenylphosphine / dichloromethane / 0.33 h / 20 - 50 °C

With tetrachloromethane; tetrabutyl ammonium fluoride; phenyl isocyanate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2012.05.012