7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Base Information

Chemical Name:7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.:69809-99-0
Molecular Formula:C₁₇H₁₈N₂O₇
Molecular Weight:362.339
Hs Code.:

7<i>c</i>-methoxy-3-methyl-8-oxo-7<i>t</i>-(2-phenoxy-acetylamino)-(6<i>r</i><i>H</i>)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Synonyms:7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Property of 7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Technology Process of 7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 7 articles about 7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69809-97-8
7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester

: 69809-99-0
7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 23 ℃; for 0.166667h; under 760 Torr;
DOI:10.1139/v78-473

Reference yield:

: 62282-24-0,69809-85-4,75767-11-2
benzyl cis-7-amino-3-methyl-2-iso-oxacephem-4-carboxylate

: 69809-99-0
7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂ / Heating

2: (i) nBuLi, iPr₂NH, hexane, DMF, (ii) /BRN= 1923546/

3: (i) TsOH*H₂O, H₂O, AcOEt, (ii) Na₂CO₃

4: EEDQ / CH₂Cl₂ / 4 h / 23 °C

5: Hg(OAc)2 / 1 h / 23 °C

6: H₂ / Pd-C / tetrahydrofuran / 0.17 h / 23 °C / 760 Torr

With mercury(II) diacetate; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1139/v78-473

Reference yield:

: 69809-87-6
3-methyl-7t-(4-nitro-benzylideneamino)-8-oxo-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester

: 69809-99-0
7c-methoxy-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: (i) nBuLi, iPr₂NH, hexane, DMF, (ii) /BRN= 1923546/

2: (i) TsOH*H₂O, H₂O, AcOEt, (ii) Na₂CO₃

3: EEDQ / CH₂Cl₂ / 4 h / 23 °C

4: Hg(OAc)2 / 1 h / 23 °C

5: H₂ / Pd-C / tetrahydrofuran / 0.17 h / 23 °C / 760 Torr

With mercury(II) diacetate; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1139/v78-473