N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

Base Information

Chemical Name:N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester
CAS No.:357429-14-2
Molecular Formula:C₂₈H₄₅N₇O₇Si
Molecular Weight:619.793
Hs Code.:

Synonyms:N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

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Chemical Property of N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

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Technology Process of N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

There total 5 articles about N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 357429-08-4
(S)-(2,5-dioxopyrrolidin-1-yl) 1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carboxylate

: L-(ω-nitro)arginyl-L-valine benzyl ester hydrochloride

: 357429-14-2
N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -10 - 20 ℃;
DOI:10.1002/1521-4184(200105)334:5<167::AID-ARDP167>3.3.CO;2-F

Reference yield:

: 2188-18-3
Boc-Arg(NO₂)-OH

: 357429-14-2
N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide

2: 3.4 g / Et₃N / CH₂Cl₂ / -10 °C

3: HCl / ethyl acetate / 4 h / 0 - 20 °C

4: 1.23 g / Et₃N / CH₂Cl₂ / -10 - 20 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1002/1521-4184(200105)334:5<167::AID-ARDP167>3.3.CO;2-F

Reference yield:

: 82938-50-9,162856-35-1
(4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid

: 357429-14-2
N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(ω-nitro)arginyl}-L-valine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 25 h / -10 - 20 °C

2: 1.23 g / Et₃N / CH₂Cl₂ / -10 - 20 °C

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1002/1521-4184(200105)334:5<167::AID-ARDP167>3.3.CO;2-F