Leuconolam sesquihydrate

Base Information

Chemical Name:Leuconolam sesquihydrate
CAS No.:93710-27-1
Molecular Formula:C₁₉H₂₂N₂O₃
Molecular Weight:326.395
Hs Code.:
DSSTox Substance ID:DTXSID80918194
Nikkaji Number:J509.223J

Synonyms:8a-ethyl-7,8,8a,10,11,12a-hexahydro-12a-hydroxyindolizino(8,1-ef)(1)benzazonine-6,13-(5H,9H)-dione;leuconolam;leuconolam sesquihydrate

Suppliers and Price of Leuconolam sesquihydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Leuconolam 95+%
5mg
$ 860.00

Arctom
Leuconolam
5mg
$ 553.00

Total 13 raw suppliers

Chemical Property of Leuconolam sesquihydrate

Chemical Property:

Vapor Pressure:5.17E-16mmHg at 25°C
Boiling Point:615.6°Cat760mmHg
Flash Point:326.1°C
PSA：69.64000
Density:1.32g/cm³
LogP:2.59920
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:326.16304257
Heavy Atom Count:24
Complexity:601

Purity/Quality:

98%min ^*data from raw suppliers

Leuconolam 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC12CCCN3C1(C(=CC3=O)C4=CC=CC=C4NC(=O)CC2)O

Technology Process of Leuconolam sesquihydrate

There total 7 articles about Leuconolam sesquihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (+)-melodinine E

: 93710-27-1,109363-24-8
(?)-leuconolam

Guidance literature:: With sulfuric acid; In tetrahydrofuran; at 40 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jacs.5b03619

Reference yield: 15.0%

: 6,7-dehydroleuconoxine

: 93710-27-1,109363-24-8
(?)-leuconolam

Guidance literature:: With hydrogenchloride; tetraethylammonium chloride; In dichloromethane; water; at 20 ℃; for 12h;
DOI:10.1021/np400922x

Reference yield:

: 128529-80-6
6β,7β-dibromodiazaspiroleuconolam

: 93710-27-1,109363-24-8
(?)-leuconolam

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; zinc / 2 h / Inert atmosphere

2: hydrogenchloride; tetraethylammonium chloride / dichloromethane; water / 12 h / 20 °C

With hydrogenchloride; tetraethylammonium chloride; acetic acid; zinc; In dichloromethane; water;
DOI:10.1021/np400922x