Technology Process of 4-chloro-6,7,8,9-tetrahydrobenzo[1,2-d]pyrimidino[5,4-b]selenophene
There total 4 articles about 4-chloro-6,7,8,9-tetrahydrobenzo[1,2-d]pyrimidino[5,4-b]selenophene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
isopropyl alcohol;
at 20 ℃;
for 1.5h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; sodium formaldehyde sulphoxylate / water / 1 h / 50 °C
1.2: 0.83 h / 60 °C
2.1: sulfuric acid / 1.25 h / 90 - 100 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux
4.1: isopropyl alcohol / 1.5 h / 20 °C / Reflux
With
thionyl chloride; sodium formaldehyde sulphoxylate; sulfuric acid; sodium hydroxide;
N,N-dimethyl-formamide;
In
water; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / 1.25 h / 90 - 100 °C
2: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux
3: isopropyl alcohol / 1.5 h / 20 °C / Reflux
With
thionyl chloride; sulfuric acid;
N,N-dimethyl-formamide;
In
isopropyl alcohol;