6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Base Information

• Chemical Name: 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine
• CAS No.: 130311-75-0
• Molecular Formula: C₁₉H₁₈ClN₅S
• Molecular Weight: 383.904
• Mol file: 130311-75-0.mol

Synonyms:6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Chemical Property of 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

There total 9 articles about 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

6-(2-chlorophenyl)-3-thioacetyl-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine (130311-74-9) → 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine (130311-75-0)

Guidance literature:

With sodium hydroxide; In methanol; for 5h; Heating;

DOI:10.1248/cpb.39.3215

Reference yield: 35.0%

→ 6-(2-Chlorophenyl)-1,4-dimethyl-9-[3-(2-quinolylmethoxy)benzoyl]-7,8,9,10-tetrahydro-4H-pyrido[4',3': 4,5]thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine (160288-34-6) + 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine (130311-75-0)

Guidance literature:

Reference yield:

1-acetyl-4-piperidinone (32161-06-1) → 6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine (130311-75-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 75 percent / S, Et₃N / dimethylformamide / 1 h / 60 °C

2: 95 percent / NaHCO₃ / toluene; H₂O / 60 °C

3: liquid NH₃ / 1,2-dichloro-ethane; ethyl acetate / 1 h / 100 °C

4: pyridine, AcOH / toluene / 24 h / Heating

5: P₂S₅, NaHCO₃ / 1,2-dimethoxy-ethane / 4 h / Heating

6: dioxane / 5 h / 100 °C

7: 66 percent / 4 N aq. NaOH / methanol / 5 h / Heating

With pyridine; sodium hydroxide; tetraphosphorus decasulfide; ammonia; sodium hydrogencarbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

DOI:10.1248/cpb.39.3215

upstream raw materials:

6-(2-chlorophenyl)-3-thioacetyl-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

1-acetyl-4-piperidinone

2-Chlorobenzoyl acetonitrile

2-amino-3-(2-chlorobenzoyl)-6-acetyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

Downstream raw materials:

(+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3><1,4>-diazepine

(-)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3><1,4>-diazepine

(+)-6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

(-)-6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine