(3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

Base Information

Chemical Name:(3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester
CAS No.:284486-62-0
Molecular Formula:C₃₀H₄₃NO₈S₂
Molecular Weight:609.805
Hs Code.:

Synonyms:(3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

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Chemical Property of (3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

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Technology Process of (3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

There total 7 articles about (3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (3R,4E)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl]pent-4-enoic acid tert-butyl ester

: 284486-62-0
(3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

Guidance literature:: With (triphenylphosphine)copper(I) hydride hexamer; water; In benzene; at 25 ℃; for 3h;
DOI:10.1016/S0040-4020(99)00922-9

Reference yield: 75.0%

: 263552-40-5
(2R,3R), 3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-neopentyloxysulfonyl-pent-4-enoic acid tertiobutyl ester

: 284486-62-0
(3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

Guidance literature:: With (triphenylphosphine)copper(I) hydride hexamer; water; at 25 ℃; for 3h;
DOI:10.1021/jm9903040

Reference yield:

: 63327-57-1
(2S), 2-benzyloxycarbonylamino-succinic acid 1-methyl ester 4-tertiobutyl ester

: 284486-62-0
(3R)-3-benzyloxycarbonylamino-2-[4-methoxybenzylsulfanyl]-5-[2,2-dimethylpropanoxy sulfonyl] pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 68 percent / n-BuLi

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 68 percent / diisobutylaluminum hydride / hexane; tetrahydrofuran; toluene / 4 h / -78 - 20 °C

3.1: 75 percent / [(PPh₃)CuH]6; H₂O / 3 h / 25 °C

With n-butyllithium; (triphenylphosphine)copper(I) hydride hexamer; water; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: sulfenylation / 2.1: Metallation / 2.2: Dibal-H reduction-Wittig-Horner olefination / 3.1: Reduction;
DOI:10.1021/jm9903040