4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Base Information

Chemical Name:4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide
CAS No.:1612241-91-4
Molecular Formula:C₁₈H₁₆F₄N₆O
Molecular Weight:408.358
Hs Code.:

Synonyms:4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

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Chemical Property of 4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

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Technology Process of 4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

There total 14 articles about 4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612242-58-6
C₂₄H₁₉F₄N₇O₅S

: 1612241-91-4
4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Guidance literature:: C₂₄H₁₉F₄N₇O₅S; With potassium carbonate; In N,N-dimethyl-formamide; for 0.166667h;

With thiophenol; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1612242-47-3
3-nitro-pyridine-2,4-dicarboxylic acid diethyl ester

: 1612241-91-4
4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / 4 h / 20 °C

2.1: 96 h / 140 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

3.2: 12 h / 40 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

4.2: 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 6635-86-5,67476-70-4
2-amino-4-methyl-3-nitropyridine

: 1612241-91-4
4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium nitrite; sulfuric acid / water / 2 h / 0 - 20 °C

2.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 12 h / 20 °C / Reflux

3.1: N,N-dimethyl-formamide / 13 h / 100 °C

4.1: sulfuric acid / water / 3 h / 70 °C

5.1: hydrogenchloride; ammonium chloride; iron / water; isopropyl alcohol / Reflux

6.1: 24 h / Reflux

7.1: sulfuric acid; potassium dichromate; Pyrimidin-2(1H)-one / water / 20 - 30 °C

8.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 70 °C

8.2: 70 °C

9.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

9.2: 12 h / 40 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

10.2: 20 °C

With Pyrimidin-2(1H)-one; hydrogenchloride; potassium dichromate; sulfuric acid; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium nitrite; phosphorus(V) oxybromide; In water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;