(5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

Base Information

Chemical Name:(5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene
CAS No.:334706-69-3
Molecular Formula:C₃₂H₃₇NO
Molecular Weight:451.652
Hs Code.:

Synonyms:(5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

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Chemical Property of (5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

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Technology Process of (5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

There total 1 articles about (5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 334706-64-8
(2S,7R,9R,10S)-2-(o-bromophenyl)-3-(3',3'-diphenyl)allyl-4,4,7-trimethyl-octahydro-2H-1,3-benzoxazine

: (1R,2S,5R)-2-{1-[2-(2,2-Diphenyl-vinyl)-3-phenyl-aziridin-1-yl]-1-methyl-ethyl}-5-methyl-cyclohexanol

: 334706-69-3
(5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: (1R,2S,5R)-2-[1-(1,5-Diphenyl-1,3-dihydro-benzo[c]azepin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

Guidance literature:: (2S,7R,9R,10S)-2-(o-bromophenyl)-3-(3',3'-diphenyl)allyl-4,4,7-trimethyl-octahydro-2H-1,3-benzoxazine; With tert.-butyl lithium; In diethyl ether; pentane; at -90 ℃; for 0.166667h;

With N,N,N,N,-tetramethylethylenediamine; In diethyl ether; pentane; at -90 - 20 ℃; for 0.333333h; Further stages.;
DOI:10.1021/ja002864q

Reference yield:

: 334706-69-3
(5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: (1R,2S,5R)-2-[1-((R)-4-Benzhydryl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at -10 ℃; for 0.333333h;
DOI:10.1021/ja002864q

Reference yield:

: 334706-69-3
(5R,7aS,10R,11aR,12aS)-5-Benzhydryl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

: (R)-4-diphenylmethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄; AlCl₃ / tetrahydrofuran / 0.33 h / -10 °C

2: PCC; NaOAc; 3 A MS / CH₂Cl₂ / 2 h / 20 °C

3: 2.5 M KOH / tetrahydrofuran; methanol

With potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja002864q