(Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

Base Information

• Chemical Name: (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid
• CAS No.: 85235-31-0
• Molecular Formula: C₃₉H₆₂O₇Si
• Molecular Weight: 671.003

Synonyms:(Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

Chemical Property of (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

There total 4 articles about (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid tetrahydro-pyran-2-yl ester (85235-30-9) → (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid (85235-31-0)

Guidance literature:

With potassium hydroxide; In methanol; water; at 25 ℃; for 20h;

DOI:10.1021/jm00360a003

Reference yield:

(4-carboxybutyl)triphenylphosphonium bromide (17814-85-6) → (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid (85235-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) HMPA, 70 deg C, 3 h, 2.) HMPA, THF, 10-15 deg C, 1.5 h

2: pyridine hydrochloride / CH₂Cl₂ / 48 h / 25 °C

3: KOH / methanol; H₂O / 20 h / 25 °C

With potassium hydroxide; pyridine hydrochloride; sodium hydride; In methanol; dichloromethane; water;

DOI:10.1021/jm00360a003

Reference yield:

(3aR,4R,5R,6aS)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-2-ol (85235-23-0) → (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid (85235-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) HMPA, 70 deg C, 3 h, 2.) HMPA, THF, 10-15 deg C, 1.5 h

2: pyridine hydrochloride / CH₂Cl₂ / 48 h / 25 °C

3: KOH / methanol; H₂O / 20 h / 25 °C

With potassium hydroxide; pyridine hydrochloride; sodium hydride; In methanol; dichloromethane; water;

DOI:10.1021/jm00360a003

upstream raw materials:

(Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid tetrahydro-pyran-2-yl ester

(4-carboxybutyl)triphenylphosphonium bromide

(3aR,4R,5R,6aS)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-2-ol

(Z)-7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-cyclopentyl}-hept-5-enoic acid

Downstream raw materials:

(Z)-7-[(1R,2R,5S)-3-Oxo-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

17-phenyl-18,19,20-trinor-PGD₂

17-phenyl-18,19,20-trinor-PGF_2α 9,15-bis(tetrahydropyranyl ether)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 85235-31-0 (Z)-7-[(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-1-enyl]-5-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send