4-(2-Methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

Base Information

• Chemical Name: 4-(2-Methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid
• CAS No.: 132785-33-2
• Molecular Formula: C14H17 N O5
• Molecular Weight: 279.293
• DSSTox Substance ID: DTXSID10157796
• Nikkaji Number: J838.956J
• Wikidata: Q83025956
• Mol file: 132785-33-2.mol

Synonyms:4-(2-methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid;MFPA

Chemical Property of 4-(2-Methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

Chemical Property:

• Vapor Pressure: 7.78E-12mmHg at 25°C
• Boiling Point: 524.7°Cat760mmHg
• Flash Point: 271.1°C
• PSA: 95.86000
• Density: 1.284g/cm³
• LogP: 1.25490
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 279.11067264
• Heavy Atom Count: 20
• Complexity: 373

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2CNC(C2CC(=O)O)C(=O)O
• Isomeric SMILES: COC1=CC=CC=C1[C@H]2CN[C@@H]([C@H]2CC(=O)O)C(=O)O

Technology Process of 4-(2-Methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

There total 59 articles about 4-(2-Methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,3S,4S)-3-Carboxymethyl-4-(2-methoxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester → MFPA (132785-33-2)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1016/S0040-4039(02)01817-8

Reference yield: 95.0%

di-tert-butyl (2S,3S,4S)-3-(2-(tert-butoxy)-2-oxoethyl)-4-(2-methoxyphenyl)pyrrolidine-1,2-dicarboxylate (1532518-99-2) → MFPA (132785-33-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol403434e

Reference yield: 90.0%

2-[(2S,3S,4S)-1,2-di-(tert-butoxycarbonyl)-4-(2-methoxyphenyl)pyrrolidin-3-yl]acetic acid (1218815-80-5) → MFPA (132785-33-2)

Guidance literature:

2-[(2S,3S,4S)-1,2-di-(tert-butoxycarbonyl)-4-(2-methoxyphenyl)pyrrolidin-3-yl]acetic acid; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja909457b

upstream raw materials:

(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(2-methoxy-phenyl)-pyrrolidine-2-carboxylic acid methyl ester

(2S,3S,4S)-N-benzoyl-2-methoxycarbonyl-3-methoxycarbonylmethyl-4-(2-methoxyphenyl)pyrrolidine

2-methoxyphenethyl alcohol

2-methoxyphenylacetic acid