(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

Base Information

Chemical Name:(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate
CAS No.:226388-23-4
Molecular Formula:C₃₄H₃₄N₂O₃
Molecular Weight:518.656
Hs Code.:

Synonyms:(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

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Chemical Property of (αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

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Technology Process of (αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

There total 1 articles about (αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (αRS,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-bromo-α-phenylacetate

: 103-49-1
dibenzylamine

: (αS,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

: 226388-23-4
(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

Guidance literature:: With sodium iodide; In acetonitrile; at 60 ℃; for 48h; Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(99)00018-X

Reference yield: 71.0%

: 226388-23-4
(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

: 226388-27-8
(R)-α-(N,N-dibenzylamino)-α-phenylacetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 72h; Ambient temperature;
DOI:10.1016/S0957-4166(99)00018-X

Reference yield:

: 226388-23-4
(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl α-(N,N-dibenzylamino)-α-phenylacetate

: 25705-52-6
(R)-phenylglycine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / aq. LiOH / tetrahydrofuran / 72 h / Ambient temperature

2: H₂, aq. HCl / 10 percent Pd/C / ethanol / 1 h / 760 Torr

With hydrogenchloride; lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/S0957-4166(99)00018-X