3'5'-Anhydro thymidine

Base Information

Chemical Name:3'5'-Anhydro thymidine
CAS No.:7481-90-5
Molecular Formula:C10H12N2O4
Molecular Weight:224.216
Hs Code.:
European Community (EC) Number:425-810-5
NSC Number:98948
ChEMBL ID:CHEMBL1388678

Synonyms:3'5'-anhydro thymidine;1-(2,6-dioxabicyclo[3.2.0]heptan-3-yl)-5-methylpyrimidine-2,4-dione;NSC98948;NCIOpen2_006423;Oprea1_576629;MLS000061743;CHEMBL1388678;SCHEMBL12303789;HMS1608G20;HMS2340J16;NSC-98948;AKOS000656177;NCGC00072256-02;SMR000070211;1-(3,5-Anhydro-2-deoxy-beta-D-threo-pentofuranosyl) thymine;1-(2,6-dioxabicyclo[3.2.0]hept-3-yl)-5-methyl-2,4(1H,3H)-pyrimidinedione (non-preferred name)

Suppliers and Price of 3'5'-Anhydro thymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
1-(3,5-Anhydro-2-deoxy-beta-D-threo-pentofuranosyl)thymine >98.0%(HPLC)(T)
5g
$ 77.00

Crysdot
1-((1R,3R,5R)-1,5-Dimethyl-2,6-dioxabicyclo[3.2.0]heptan-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 95+%
100g
$ 627.00

Chemenu
1-((1R,3R,5R)-1,5-dimethyl-2,6-dioxabicyclo[3.2.0]heptan-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 95%
100g
$ 592.00

Total 18 raw suppliers

Chemical Property of 3'5'-Anhydro thymidine

Chemical Property:

Melting Point:196oC
Refractive Index:-126 ° (C=1, 1mol/L NaOH)
PKA:9.52±0.10(Predicted)
PSA：73.32000
Density:1.412g/cm³
LogP:-0.46870
XLogP3:-0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:224.07970687
Heavy Atom Count:16
Complexity:392

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3,5-Anhydro-2-deoxy-beta-D-threo-pentofuranosyl)thymine >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC3C(O2)CO3

Technology Process of 3'5'-Anhydro thymidine

There total 10 articles about 3'5'-Anhydro thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 56822-33-4
3',5'-di-O-mesylthymidine

: 7481-90-5
3',4'-anhydrothymidine

Guidance literature:: With sodium hydroxide; for 0.75h; Heating;
DOI:10.1021/jm00122a029

Reference yield:

: 63914-08-9
3',5'-bis-O-(p-tolylsulfonyl)thymidine

: 7481-90-5
3',4'-anhydrothymidine

Guidance literature:: With potassium hydroxide; In water; for 0.75h; Reflux;

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 7481-90-5
3',4'-anhydrothymidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 20 °C

2: aq. NaOH / methanol

With pyridine; sodium hydroxide; In methanol;
DOI:10.1016/j.bmcl.2006.11.070