N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester

Base Information

• Chemical Name: N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester
• CAS No.: 1415686-73-5
• Molecular Formula: C₃₇H₅₁NO₆
• Molecular Weight: 605.815
• Mol file: 1415686-73-5.mol

Synonyms:N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester

Chemical Property of N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester

There total 4 articles about N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3β-(L-alanine)-diosgenin (1214731-19-7) + O-acetylsalicyloyl chloride (5538-51-2) → N-(2-acetoxybenzoyl)-L-alanine diosgenyl ester (1415686-72-4) + N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester (1415686-73-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1016/j.bmcl.2012.10.086

Reference yield:

diosgenin (512-04-9) → N-(2-acetoxybenzoyl)-L-alanine diosgenyl ester (1415686-72-4) + N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester (1415686-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2.2: 0 °C

3.1: triethylamine / dichloromethane / 1.5 h / 0 °C

With dmap; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.10.086

Reference yield:

aspirin (50-78-2,98201-60-6) → N-(2-acetoxybenzoyl)-L-alanine diosgenyl ester (1415686-72-4) + N-(2-hydroxybenzoyl)-L-alanine diosgenyl ester (1415686-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 70 - 75 °C

2: triethylamine / dichloromethane / 1.5 h / 0 °C

With thionyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.086

upstream raw materials:

diosgenin

aspirin

3β-(L-alanine)-diosgenin

O-acetylsalicyloyl chloride