benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

Base Information

Chemical Name:benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate
CAS No.:1080018-71-8
Molecular Formula:C₁₉H₂₃ClN₈O₃
Molecular Weight:446.896
Hs Code.:

Synonyms:benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

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Chemical Property of benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

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Technology Process of benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

There total 5 articles about benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080018-70-7
tert-butyl 4-(2-(benzyloxycarbonyl)-3-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino)-piperidine-1-carboxylate

: 1080018-71-8
benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

Guidance literature:: tert-butyl 4-(2-(benzyloxycarbonyl)-3-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino)-piperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; methanol; at 40 ℃;

With sodium hydroxide; In water; ethyl acetate; pH=8;

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 1080018-71-8
benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 6 h / 66 °C

2.1: tetrahydrofuran / Heating / reflux

3.1: hydrogenchloride / 1,4-dioxane; methanol / 40 °C

3.2: pH 8

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 76942-92-2
methyl 3,5-diamino-6-chloropyrazine-2-carbonylcarbamimidothioate hydroiodic acid salt

: 1080018-71-8
benzyl (3,5-diamino-6-chloropyrazine-2-carboxamido)(piperidin-4-ylamino)methylenecarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 6 h / 66 °C

2.1: tetrahydrofuran / Heating / reflux

3.1: hydrogenchloride / 1,4-dioxane; methanol / 40 °C

3.2: pH 8

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;