2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone

Base Information

• Chemical Name: 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone
• CAS No.: 262425-31-0
• Molecular Formula: C₂₁H₁₄O₃S
• Molecular Weight: 346.406
• Mol file: 262425-31-0.mol

Synonyms:2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone

Chemical Property of 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone

There total 3 articles about 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)-(2-methoxyphenyl)ketone (262425-29-6) → 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone (262425-31-0)

Guidance literature:

With aluminium trichloride; ethanethiol; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm9903388

Reference yield:

2-(4-methoxyphenyl)benzo[b]thiophene (27884-09-9) → 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone (262425-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / AlCl₃ / 1,2-dichloro-ethane / 5 h / 0 °C

2: 1.00 g / AlCl₃; EtSH / CH₂Cl₂ / 2 h / 20 °C

With aluminium trichloride; ethanethiol; In dichloromethane; 1,2-dichloro-ethane; 1: Acylation / 2: demethylation;

DOI:10.1021/jm9903388

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) → 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 2-hydroxyphenyl ketone (262425-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / AlCl₃ / 1,2-dichloro-ethane / 5 h / 0 °C

2: 1.00 g / AlCl₃; EtSH / CH₂Cl₂ / 2 h / 20 °C

With aluminium trichloride; ethanethiol; In dichloromethane; 1,2-dichloro-ethane; 1: Acylation / 2: demethylation;

DOI:10.1021/jm9903388

upstream raw materials:

(2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)-(2-methoxyphenyl)ketone

2-(4-methoxyphenyl)benzo[b]thiophene

2-Methoxybenzoyl chloride