4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

Base Information

Chemical Name:4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine
CAS No.:215303-34-7
Molecular Formula:C₂₀H₂₄FN₃OSi
Molecular Weight:369.514
Hs Code.:

Synonyms:4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

Suppliers and Price of 4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

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Technology Process of 4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

There total 4 articles about 4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: PTsOH_.H₂O

: 181630-93-3
4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole

: 215303-34-7
4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; hexane; tert-butyl methyl ether; orthoformic acid triethyl ester;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 5-(4-fluoro-phenyl)-4-(4-pyridyl)-imidazole

: 215303-34-7
4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

Guidance literature:: In N-methyl-acetamide; water; mineral oil;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 5-(4-fluoro-phenyl)-4-(4-pyridyl)-imidazole

: 215303-25-6
4-(4-fluorophenyl)-5-(pyridin-4-yl)-1-(2-(trimethylsilyl)-ethoxymethyl)-imidazole

: 215303-34-7
4-[5-(4-fluoro-phenyl)-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-imidazol-4-yl]-pyridine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Title compound not separated from byproducts;
DOI:10.1016/S0968-0896(00)00331-X