(S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Chemical Name:(S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea
CAS No.:1450733-51-3
Molecular Formula:C₃₃H₄₃N₃O₅
Molecular Weight:561.722
Hs Code.:

Synonyms:(S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Chemical Property of (S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Technology Process of (S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

There total 4 articles about (S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1450733-39-7
(S)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 1450733-48-8
(S)-1-(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

: 1450733-51-3
(S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 55707-43-2
(S)-1-benzyl-2,2-dimethoxyethan-1-amine

: 1450733-51-3
(S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With sodium hydride; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 59830-61-4
(S)-(1-benzyl-2,2-dimethoxyethyl)carbamic acid benzyl ester

: 1450733-51-3
(S)-1,3-di(3-methoxybenzyl)-3-(1-benzyl-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C

2.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; sodium hydride; methyl iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.06.018