methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

Base Information

Chemical Name:methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate
CAS No.:220223-16-5
Molecular Formula:C₂₃H₃₀N₂O₆S
Molecular Weight:462.567
Hs Code.:

Synonyms:methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

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Chemical Property of methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

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Technology Process of methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

There total 4 articles about methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 220223-15-4
2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl chloride

: 220223-16-5
methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

Guidance literature:: With 4-methyl-morpholine; In acetonitrile; for 3h; Heating;
DOI:10.1016/S0040-4020(98)01029-1

Reference yield:

: 69026-14-8
3-benzyloxybenzoic acid

: 220223-16-5
methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: SOCl₂ / benzene / 1 h / Heating

2.1: 13.6 g / benzene / 0.75 h / Heating

3.1: TMEDA; tert-BuLi / diethyl ether; hexane / 1 h / -78 °C

3.2: sulfur dioxide / diethyl ether; hexane / 1.25 h / -78 - 20 °C

3.3: 68 percent / sodium phosphate; N-chlorosuccinimide / H₂O; ethyl acetate / 1 h / pH 6.0 / ice-cooling

4.1: 83 percent / N-methylmorpholine / acetonitrile / 3 h / Heating

With 4-methyl-morpholine; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In diethyl ether; hexane; acetonitrile; benzene; 1.1: Substitution / 2.1: Acylation / 3.1: Metallation / 3.2: sulfinylation / 3.3: Chlorination / 4.1: Substitution;
DOI:10.1016/S0040-4020(98)01029-1

Reference yield:

: 61535-46-4
3-benzyloxy-benzoyl chloride

: 220223-16-5
methyl N-[2-benzyloxy-6-(N,N-diisopropylcarbamyl)benzenesulfonyl]glycinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 13.6 g / benzene / 0.75 h / Heating

2.1: TMEDA; tert-BuLi / diethyl ether; hexane / 1 h / -78 °C

2.2: sulfur dioxide / diethyl ether; hexane / 1.25 h / -78 - 20 °C

2.3: 68 percent / sodium phosphate; N-chlorosuccinimide / H₂O; ethyl acetate / 1 h / pH 6.0 / ice-cooling

3.1: 83 percent / N-methylmorpholine / acetonitrile / 3 h / Heating

With 4-methyl-morpholine; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In diethyl ether; hexane; acetonitrile; benzene; 1.1: Acylation / 2.1: Metallation / 2.2: sulfinylation / 2.3: Chlorination / 3.1: Substitution;
DOI:10.1016/S0040-4020(98)01029-1