(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

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Chemical Name:(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid
CAS No.:96865-77-9
Molecular Formula:2C₂HF₃O₂*C₁₈H₂₁N₉O₃
Molecular Weight:639.471
Hs Code.:

Synonyms:(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

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Chemical Property of (S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

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Technology Process of (S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

There total 6 articles about (S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 100484-54-6
N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^β-(tert-butyloxycarbonyl)-L-2,3-diaminopropionic acid

: 76-05-1
trifluoroacetic acid

: 96865-77-9
(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

Guidance literature:: at 0 - 5 ℃; for 1h;
DOI:10.1021/jm00146a008

Reference yield:

: 96845-94-2
ethyl N²-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-N³-<(1,1-dimethylethoxy)carbonyl>-2,3-diaminopropanoic acid

: 96865-77-9
(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / (i-Pr)2NEt / dimethylformamide / 120 h / 20 - 25 °C

2: 97 percent / H₂ / 5percent Pd/C / dioxane / 760 Torr / Ambient temperature

3: 79 percent / N,N-dimethyl-acetamide / 144 h

4: 86 percent / NaOH / ethanol / 4 h / 20 - 25 °C

5: 99 percent / 1 h / 0 - 5 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00146a008

Reference yield:

: 96845-90-8
ethyl N²-<4-<<(benzyloxy)carbonyl>methylamino>benzoyl>-N³-<(1,1-dimethylethoxy)carbonyl>-2,3-diaminopropanoate

: 96865-77-9
(S)-3-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propionic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / 5percent Pd/C / dioxane / 760 Torr / Ambient temperature

2: 79 percent / N,N-dimethyl-acetamide / 144 h

3: 86 percent / NaOH / ethanol / 4 h / 20 - 25 °C

4: 99 percent / 1 h / 0 - 5 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00146a008