5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone

Base Information

Chemical Name:5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone
CAS No.:111711-93-4
Molecular Formula:C12H15 N O5 S
Molecular Weight:285.321
Hs Code.:
DSSTox Substance ID:DTXSID90920546
Nikkaji Number:J423.484G

Synonyms:BRN 4757091;111711-93-4;5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone;2-Pyrrolidinone, 5-ethoxy-1-((4-hydroxyphenyl)sulfonyl)-;SCHEMBL9670751;DTXSID90920546;WYCLOXANJRCQET-UHFFFAOYSA-N;LS-138771;1-(4-hydroxybenzenesulphonyl)-2-oxo-5-ethoxypyrrolidine;5-Ethoxy-1-[[4-hydroxyphenyl]sulfonyl]pyrrolidin-2-one;5-Ethoxy-1-(4-hydroxybenzene-1-sulfonyl)pyrrolidin-2-one

Suppliers and Price of 5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone

Chemical Property:

Vapor Pressure:4.08E-09mmHg at 25°C
Boiling Point:460.9°C at 760 mmHg
Flash Point:232.6°C
Density:1.44g/cm³
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:285.06709375
Heavy Atom Count:19
Complexity:422

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1CCC(=O)N1S(=O)(=O)C2=CC=C(C=C2)O

Technology Process of 5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone

There total 5 articles about 5-Ethoxy-1-((4-hydroxyphenyl)sulfonyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 111711-62-7
1-(4-benzyloxyphenylsulphonyl)-5-ethoxypyrrolidin-2-one

: 111711-93-4
5-ethoxy-1-(4-hydroxyphenylsulfonyl)-2-pyrrolidinone

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;
DOI:10.1016/0223-5234(91)90101-R

Reference yield:

: 39662-63-0
5-ethoxy-pyrrolidin-2-one

: 111711-93-4
5-ethoxy-1-(4-hydroxyphenylsulfonyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 45 min, 2.) THF, hexane, -70 deg C, 2 h

2: 52 percent / H₂ / 10percent Pd/C / aq. ethanol / 760 Torr / Ambient temperature

With n-butyllithium; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/0223-5234(91)90101-R

Reference yield:

: 825-90-1
sodium p-hydroxybenzenesulfonate

: 111711-93-4
5-ethoxy-1-(4-hydroxyphenylsulfonyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 34.3 g / 15percent aq. NaOH / aq. ethanol / 5 h / Heating

2: 65 percent / phosphorus pentachloride / CH₂Cl₂ / 7 h / Heating

3: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 45 min, 2.) THF, hexane, -70 deg C, 2 h

4: 52 percent / H₂ / 10percent Pd/C / aq. ethanol / 760 Torr / Ambient temperature

With sodium hydroxide; n-butyllithium; phosphorus pentachloride; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/0223-5234(91)90101-R