(1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

Base Information

Chemical Name:(1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol
CAS No.:178379-72-1
Molecular Formula:C₁₇H₃₀O₂
Molecular Weight:266.424
Hs Code.:

Synonyms:(1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

Suppliers and Price of (1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

Chemical Property:

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Technology Process of (1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

There total 10 articles about (1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 392235-04-0
(1S,3aS,5S,7aR)-1-hydroxymethyl-5-phenyl-7a-methylperhydroinden-3a-ol

: 178379-72-1
(1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

Guidance literature:: With hydrogen; 5percent Rh/Al₂₀₃; In methanol; for 4h; under 3268.22 Torr;
DOI:10.1021/jm011001k

Reference yield:

: 33879-04-8,51065-67-9
(+)-(3aS,7aS)-2,3,3a,4,7,7a-hexahydro-3a-hydroxy-7a-methyl-1H-indene-1,5(6H)-dione

: 178379-72-1
(1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 83 percent / oxalic acid / acetonitrile / 16 h

2.1: 77 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 2 h / Heating

3.1: BH₃ / tetrahydrofuran / 1 h / 20 °C

3.2: 20 percent / NaBO₃; aq. NaOH / 16 h / 20 °C

4.1: 68 percent / 1 N pTSA / acetonitrile; H₂O / 16 h

5.1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C

6.1: 82 percent / Raney-Ni / ethanol; H₂O / 3 h / Heating

7.1: 100 percent / H₂ / 5percent Rh/Al₂₀₃ / methanol / 4 h / 3268.22 Torr

With borane; potassium tert-butylate; hydrogen; oxalic acid; nickel; toluene-4-sulfonic acid; 5percent Rh/Al₂₀₃; In tetrahydrofuran; methanol; diethyl ether; ethanol; cyclohexane; water; acetonitrile; tert-butyl alcohol; 2.1: Wittig reaction;
DOI:10.1021/jm011001k

Reference yield:

: 591-51-5
phenyllithium

: 178379-72-1
(1S,3aS,5S,7aR)-1-hydroxymethyl-5-cyclohexyl-7a-methylperhydroinden-3a-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C

2: 82 percent / Raney-Ni / ethanol; H₂O / 3 h / Heating

3: 100 percent / H₂ / 5percent Rh/Al₂₀₃ / methanol / 4 h / 3268.22 Torr

With hydrogen; nickel; 5percent Rh/Al₂₀₃; In tetrahydrofuran; methanol; diethyl ether; ethanol; cyclohexane; water;
DOI:10.1021/jm011001k