4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride

Base Information

• Chemical Name: 4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride
• CAS No.: 853755-36-9
• Molecular Formula: C₁₆H₁₈Cl₂N₂O₄
• Molecular Weight: 373.236

Synonyms:4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride

Chemical Property of 4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride

Chemical Property:

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Technology Process of 4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride

There total 2 articles about 4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[3-(3-Carboxy-propylcarbamoyl)-benzoylamino]-butyric acid (853755-35-8) → 4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride (853755-36-9)

Guidance literature:

With oxalyl dichloride; In pyridine; toluene;

DOI:10.1016/j.bmcl.2005.03.002

Reference yield:

benzene-1,3-dicarbonyl dichloride (99-63-8) → 4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride (853755-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / diethyl ether

2: C₂O₂Cl₂ / pyridine; toluene

With sodium hydroxide; oxalyl dichloride; In pyridine; diethyl ether; toluene;

DOI:10.1016/j.bmcl.2005.03.002

Reference yield: 25.0%

4-[3-(3-chlorocarbonyl-propylcarbamoyl)-benzoylamino]-butyryl chloride (853755-36-9) + (R)-3-(biphenyl-4-ylsulfonamido)-4-tert-butoxy-4-oxobutan-1-aminium acetate (1206630-99-0) → C56H68N6O12S2 (1206631-00-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

upstream raw materials:

4-[3-(3-Carboxy-propylcarbamoyl)-benzoylamino]-butyric acid

benzene-1,3-dicarbonyl dichloride

Downstream raw materials:

2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-4-{4-[3-(3-{3-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-3-tert-butoxycarbonyl-propylcarbamoyl}-propylcarbamoyl)-benzoylamino]-butyrylamino}-butyric acid tert-butyl ester

(R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-4-{4-[3-(3-{(R)-3-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-3-carboxy-propylcarbamoyl}-propylcarbamoyl)-benzoylamino]-butyrylamino}-butyric acid

C₆₆H₉₄N₈O₁₄S₂Si₂

C₅₆H₆₈N₆O₁₂S₂

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