benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate

Base Information

• Chemical Name: benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate
• CAS No.: 127626-47-5
• Molecular Formula: C₃₃H₃₅ClN₆O₇S₂
• Molecular Weight: 727.262

Synonyms:benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate

Chemical Property of benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate

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Technology Process of benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate

There total 1 articles about benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-[(1-tert-butoxycarbonyl-1-methylethoxy)imino]acetyl chloride hydrochloride (116856-00-9) + (6R)-trans-3-chloromethyl-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, diphenylmethyl ester → benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate (127626-47-5)

Guidance literature:

With N-Trimethylsilylacetamide; In tetrahydrofuran; at 35 ℃; for 1h;

DOI:10.1016/j.bmc.2007.11.074

Reference yield: 88.0%

benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(chloromethyl)-3-cephem-4-carboxylate (127626-47-5) → benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(iodomethyl)-3-cephem-4-carboxylate (689293-71-8)

Guidance literature:

With Aliquat 336; sodium iodide; In phosphate buffer; toluene; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2007.11.074

upstream raw materials:

(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-[(1-tert-butoxycarbonyl-1-methylethoxy)imino]acetyl chloride hydrochloride

Downstream raw materials:

benzhydryl 7β-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetamido]-3-(iodomethyl)-3-cephem-4-carboxylate

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