N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine

Base Information

• Chemical Name: N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine
• CAS No.: 88084-38-2
• Molecular Formula: C₃₁H₄₄N₆O₄
• Molecular Weight: 564.728

Synonyms:N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine

Chemical Property of N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine

There total 8 articles about N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

L-arginine (74-79-3,25212-18-4) + (S)-1-(4-Phenyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-1-methyl-2-phenyl-ethyl)-amide (88084-22-4) → Nα-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine (88084-38-2)

Guidance literature:

With sodium cyanoborohydride; In isopropyl alcohol;

DOI:10.1021/jm00369a017

Reference yield:

phenylbutyric acid chloride (18496-54-3) → Nα-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine (88084-38-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / pyridine / CH₂Cl₂ / 3 h / 25 °C

2: 79 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: 58 percent / HOBt, DCC / tetrahydrofuran / 2.5 h / 25 °C

4: 59 percent / (COCl)2, DMSO / CH₂Cl₂ / 0.25 h / -60 °C

5: 7 percent / NaCNBH₃ / propan-2-ol

With pyridine; oxalyl dichloride; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; dimethyl sulfoxide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00369a017

Reference yield:

N-(4-phenylbutyryl)-L-proline benzyl ester (88105-73-1) → Nα-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine (88084-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 79 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: 58 percent / HOBt, DCC / tetrahydrofuran / 2.5 h / 25 °C

3: 59 percent / (COCl)2, DMSO / CH₂Cl₂ / 0.25 h / -60 °C

4: 7 percent / NaCNBH₃ / propan-2-ol

With oxalyl dichloride; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; dimethyl sulfoxide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00369a017

upstream raw materials:

L-arginine

(S)-1-(4-Phenyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-1-methyl-2-phenyl-ethyl)-amide

2-amino-2-methyl-3-phenylpropan-1-ol

2-methyl-3-phenylalanine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 88084-38-2 N^α-[N-(4-phenylbutyryl)-L-propyl-DL-2-amino-2-methyl-3-phenylpropyl]-L-arginine

Send

Send

Metric Ton KG G Pound L ML

Send

Send