diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

Base Information

Chemical Name:diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate
CAS No.:166394-77-0
Molecular Formula:C₂₃H₂₉N₂O₆P
Molecular Weight:460.467
Hs Code.:

Synonyms:diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

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Chemical Property of diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

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Technology Process of diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

There total 4 articles about diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1026878-65-8
[4-(2-Cyano-4,5-dimethoxy-phenylcarbamoyl)-benzyl]-phosphonic acid diisopropyl ester

: 166394-77-0
diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In ethanol; for 24h;
DOI:10.1021/jm9506938

Reference yield:

: 26961-27-3
2-amino-4,5-dimethoxybenzonitrile

: 166394-77-0
diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 82 percent / 30percent aq. H₂O₂, NaOH / ethanol / 24 h

With pyridine; sodium hydroxide; dihydrogen peroxide; In ethanol;
DOI:10.1021/jm9506938

Reference yield:

: 623152-10-3
(4-Chlorocarbonyl-benzyl)-phosphonic acid diisopropyl ester

: 166394-77-0
diisopropyl 4-(4-hydroxy-6,7-dimethoxyquinazolin-2-yl)benzylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 82 percent / 30percent aq. H₂O₂, NaOH / ethanol / 24 h

With pyridine; sodium hydroxide; dihydrogen peroxide; In ethanol;
DOI:10.1021/jm9506938