4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

Base Information

Chemical Name:4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione
CAS No.:1293368-06-5
Molecular Formula:C₁₉H₁₆F₂N₂O₅
Molecular Weight:390.343
Hs Code.:

Synonyms:4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

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Chemical Property of 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

Chemical Property:

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Technology Process of 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

There total 5 articles about 4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1293368-07-6
4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

: 1293368-06-5
4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

Guidance literature:: 4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione; With boron tribromide; In dichloromethane; at -30 - 20 ℃; Inert atmosphere;

With ammonium chloride; In dichloromethane;

Reference yield:

: 64248-62-0
3,4-Difluorobenzonitrile

: 1293368-06-5
4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / acetonitrile / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 70 °C / Reflux

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With water; boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1269055-90-4
4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzonitrile

: 1293368-06-5
4-[4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 70 °C / Reflux

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With water; boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;