1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide

Base Information

Chemical Name:1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide
CAS No.:133166-51-5
Molecular Formula:C₁₆H₁₁BrClFN₂O₄S
Molecular Weight:461.696
Hs Code.:

Synonyms:1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide

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Chemical Property of 1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide

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Technology Process of 1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide

There total 2 articles about 1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: [1-(4-Bromo-2-fluoro-benzyl)-6-chloro-2,4-dioxo-1,4-dihydro-2H-2λ⁴-benzo[1,2,6]thiadiazin-3-yl]-acetic acid tert-butyl ester

: 133166-51-5
1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 10h;
DOI:10.1021/jm00108a038

Reference yield:

: 133166-96-8
N-<2-<<(4-bromo-2-fluorophenyl)methyl>amino>-6-chlorobenzoyl>glycine 1,1-dimethylethyl ester

: 133166-51-5
1-<(4-bromo-2-fluorophenyl)methyl>-6-chloro-1,4-dihydro-4-oxo-3H-2,1,3-benzothiadiazine-3-acetic acid 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.75 g / SOCl₂ / toluene / 5 h / 90 °C

2: 45.3 percent / CF₃CO₂H / CH₂Cl₂ / 10 h

With thionyl chloride; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jm00108a038