2-Chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline

Base Information

Chemical Name:2-Chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline
CAS No.:352549-46-3
Molecular Formula:C₁₅H₁₈ClN₃O₂
Molecular Weight:307.78
Hs Code.:
DSSTox Substance ID:DTXSID301325486
ChEMBL ID:CHEMBL1349358
Mol file:352549-46-3.mol

Synonyms:2-chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline;2-chloro-6,7-dimethoxy-4-piperidin-1-ylquinazoline;2-chloro-6,7-dimethoxy-4-(piperidin-1-yl)quinazoline;352549-46-3;MLS000727508;2-chloro-6,7-dimethoxy-4-piperidin-1-yl-quinazoline;SCHEMBL3318391;CHEMBL1349358;DTXSID301325486;HMS2695J08;AKOS001680371;SMR000306205;AH-262/31834007;SR-01000085704;SR-01000085704-1

Suppliers and Price of 2-Chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-CHLORO-6,7-DIMETHOXY-4-(1-PIPERIDINYL)QUINAZOLINE 95.00%
5MG
$ 500.94

Total 2 raw suppliers

Chemical Property of 2-Chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:307.1087545
Heavy Atom Count:21
Complexity:341

Purity/Quality:

98% ^*data from raw suppliers

2-CHLORO-6,7-DIMETHOXY-4-(1-PIPERIDINYL)QUINAZOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)N3CCCCC3)OC

Technology Process of 2-Chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline

There total 1 articles about 2-Chloro-6,7-dimethoxy-4-(1-piperidinyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 352549-46-3
2-chloro-6,7-dimethoxy-4-piperidin-1-yl-quinazoline

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 10h;
DOI:10.1016/j.bmc.2008.05.036

Reference yield: 16.0%

: 951004-04-9
1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-ylamine

: 352549-46-3
2-chloro-6,7-dimethoxy-4-piperidin-1-yl-quinazoline

: (6,7-dimethoxy-4-piperidin-1-yl-quinazolin-2-yl)-[1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-yl]-amine

Guidance literature:: In ethylene glycol; at 220 ℃; for 0.333333h; Product distribution / selectivity; microwave irradiation;

Reference yield:

: 352549-46-3
2-chloro-6,7-dimethoxy-4-piperidin-1-yl-quinazoline

: 2-(4-(benzyloxy)phenyl)-1-(4-(6,7-dimethoxy-4-(piperidin-1-yl)quinazolin-2-yl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: butan-1-ol / 24 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.ejmech.2017.10.026