1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

Base Information

Chemical Name:1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea
CAS No.:1623011-18-6
Molecular Formula:C₂₂H₂₅BrN₄O₂S
Molecular Weight:489.436
Hs Code.:

Synonyms:1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

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Chemical Property of 1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

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Technology Process of 1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

There total 9 articles about 1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(2-aminoethyl)-4-benzylpiperidin-4-ol

: C₈H₃BrN₂OS

: 1623011-18-6
1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

Guidance literature:: With triethylamine; In dichloromethane; for 1h;
DOI:10.1002/cmdc.201402087

Reference yield:

: 1625612-35-2
C₈H₄BrNO₂S

: 1623011-18-6
1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

2: toluene / 1 h / 110 °C

3: triethylamine / dichloromethane / 1 h

With diphenyl phosphoryl azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402087

Reference yield:

: C₈H₃BrN₂S

: 1623011-18-6
1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(3-bromothieno-[3,2-b]pyridin-7-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol / 90 °C

2: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide

3: toluene / 1 h / 110 °C

4: triethylamine / toluene; dichloromethane / 1 h / 20 °C

With diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Curtius Rearrangement;
DOI:10.1016/j.bmcl.2014.09.089