1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

Base Information

Chemical Name:1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine
CAS No.:99236-82-5
Molecular Formula:C₂₃H₃₂N₄O₃SSi
Molecular Weight:472.684
Hs Code.:

Synonyms:1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

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Chemical Property of 1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

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Technology Process of 1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

There total 7 articles about 1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1-benzyl-6-oxo-9-<(1R,3R)-1,3-bis(p-tolylsulfonyloxymethyl)-4-tert-butyldimethylsilyloxy-2-oxabutyl>-9H-purine

: 99051-98-6
1-benzyl-6-oxo-9-<(2R,6R)-6-hydroxymethyl-1-oxa-4-thiacyclohexan-2-yl>-9H-purine

: 99236-82-5
1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

Guidance literature:: With sodium sulfide; In ethanol; for 42h; Heating;
DOI:10.1139/v85-354

Reference yield:

: 58-63-9,5627-16-7,5768-53-6,7013-16-3,10517-16-5,21138-24-9,21138-46-5,25583-08-8,26188-03-4,29303-00-2,31106-01-1,38183-47-0,72496-54-9
inosine

: 99236-82-5
1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / NaHCO₃ / dimethylformamide / 6 h / 90 °C

2: 98 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: sodium metaperiodate / ethanol / 24 h / Ambient temperature

4: sodium borohydride / methanol; H₂O / 12 h / Ambient temperature

5: 17 percent / pyridine / 72 h / Ambient temperature

6: 9 percent / Na₂S / ethanol / 42 h / Heating

With 1H-imidazole; sodium sulfide; sodium tetrahydroborate; sodium periodate; sodium hydrogencarbonate; In pyridine; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1139/v85-354

Reference yield:

: 100-44-7
benzyl chloride

: 99236-82-5
1-benzyl-6-oxo-9-<(2R,6R)-6-tertbutyldimethylsilyloxymethyl-1-oxa-4-thiacyclohexane-2-yl>-9H-purine

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / NaHCO₃ / dimethylformamide / 6 h / 90 °C

2: 98 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: sodium metaperiodate / ethanol / 24 h / Ambient temperature

4: sodium borohydride / methanol; H₂O / 12 h / Ambient temperature

5: 17 percent / pyridine / 72 h / Ambient temperature

6: 9 percent / Na₂S / ethanol / 42 h / Heating

With 1H-imidazole; sodium sulfide; sodium tetrahydroborate; sodium periodate; sodium hydrogencarbonate; In pyridine; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1139/v85-354