3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Base Information

Chemical Name:3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine
CAS No.:1558007-82-1
Molecular Formula:C₁₈H₁₉FN₄O₂
Molecular Weight:342.373
Hs Code.:

Synonyms:3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

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Chemical Property of 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

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Technology Process of 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

There total 4 articles about 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 936250-20-3,1430754-36-1
3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1346818-23-2
5-bromo-3-[(R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridin-2-ylamine

: 1558007-82-1
3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 110 ℃; for 1.5h;
DOI:10.1021/jm401805h

Reference yield:

: 691872-15-8
5-bromo-3-hydroxy-2-nitropyridine

: 1558007-82-1
3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 18 h / 0 - 20 °C

2: acetic acid; iron / 1,4-dioxane / 0.5 h / 20 - 40 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 1.5 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; iron; sodium hydrogencarbonate; acetic acid; triphenylphosphine; In 1,4-dioxane; water; toluene; 1: |Mitsunobu Displacement / 3: |Suzuki Coupling;
DOI:10.1021/jm401805h

Reference yield:

: (S)-1-(5-fluoro-2-methoxyphenyl)ethanol

: 1558007-82-1
3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(5-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 18 h / 0 - 20 °C

2: acetic acid; iron / 1,4-dioxane / 0.5 h / 20 - 40 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 1.5 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; iron; sodium hydrogencarbonate; acetic acid; triphenylphosphine; In 1,4-dioxane; water; toluene; 1: |Mitsunobu Displacement / 3: |Suzuki Coupling;
DOI:10.1021/jm401805h