6-bromo-7-(3-fluorophenyl)-N²-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Base Information

• Chemical Name: 6-bromo-7-(3-fluorophenyl)-N²-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide
• CAS No.: 1352087-07-0
• Molecular Formula: C₁₉H₂₂BrFN₄O₂
• Molecular Weight: 437.312

Synonyms:6-bromo-7-(3-fluorophenyl)-N²-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property of 6-bromo-7-(3-fluorophenyl)-N²-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property:

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Technology Process of 6-bromo-7-(3-fluorophenyl)-N²-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

There total 13 articles about 6-bromo-7-(3-fluorophenyl)-N²-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxamide (1352087-67-2) + Tert-butyl isocyanate (1609-86-5) → 6-bromo-7-(3-fluorophenyl)-N2-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352087-07-0)

Guidance literature:

With triethylamine; at 0 - 20 ℃; for 1h;

Reference yield:

ethyl 6-chloro-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylate (1352087-60-5) → 6-bromo-7-(3-fluorophenyl)-N2-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352087-07-0)

Guidance literature:

Multi-step reaction with 8 steps

1: dichloromethane / 0.5 h / 20 °C

2: ammonium formate / palladium 10% on activated carbon / methanol / 0.75 h / Reflux

3: N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 20 °C

4: sodium hydroxide; water / ethanol / 48 h / 70 °C

5: tetrahydrofuran / 1 h / 50 °C

6: ammonium hydroxide / water / 5.5 h / 90 °C / autoclave

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: triethylamine / 1 h / 0 - 20 °C

With ammonium hydroxide; N-Bromosuccinimide; water; ammonium formate; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

2-tert-butyl 8-ethyl 6-chloro-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxylate (1352087-61-6) → 6-bromo-7-(3-fluorophenyl)-N2-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352087-07-0)

Guidance literature:

Multi-step reaction with 7 steps

1: ammonium formate / palladium 10% on activated carbon / methanol / 0.75 h / Reflux

2: N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 20 °C

3: sodium hydroxide; water / ethanol / 48 h / 70 °C

4: tetrahydrofuran / 1 h / 50 °C

5: ammonium hydroxide / water / 5.5 h / 90 °C / autoclave

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7: triethylamine / 1 h / 0 - 20 °C

With ammonium hydroxide; N-Bromosuccinimide; water; ammonium formate; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

upstream raw materials:

6-bromo-7-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxamide

Tert-butyl isocyanate

3-(3-Fluorophenyl)acrylic acid ethyl ester

ethyl 4-(3-fluorophenyl)-1H-pyrrole-3-carboxylate

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