[(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

Base Information

Chemical Name:[(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid
CAS No.:145629-21-6
Molecular Formula:C₁₈H₁₃ClN₂O₇
Molecular Weight:404.763
Hs Code.:

Synonyms:[(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

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Chemical Property of [(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

Chemical Property:

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Technology Process of [(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

There total 9 articles about [(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(5-Chloro-6-methoxymethoxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid ethyl ester

: 145629-21-6
[(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 36h; Yield given; Heating;
DOI:10.1021/ja00055a025

Reference yield:

: 95-88-5
4-Chlororesorcinol

: 145629-21-6
[(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) HCl(g), 2.) H₂O / 1.) Et₂O, 0 deg C, 2 h, 2.) reflux

2: 49 percent / Et₃N / tetrahydrofuran / 3 h / Ambient temperature

3: K₂CO₃ / acetone / 5 h / Heating

4: ethanol. KOH / 2 h / Heating

5: (COCl)2, DMF / tetrahydrofuran; CH₂Cl₂ / 1 h / Ambient temperature

6: NaHCO₃ / H₂O; tetrahydrofuran; CH₂Cl₂ / 0.75 h

7: 2 M aq. HCl / dioxane / 36 h / Heating

With hydrogenchloride; potassium hydroxide; oxalyl dichloride; water; sodium hydrogencarbonate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;
DOI:10.1021/ja00055a025

Reference yield:

: 131088-02-3
2,4-dihydroxy-5-chlorobenzaldehyde

: 145629-21-6
[(5-Chloro-6-hydroxy-benzofuran-2-carbonyl)-(2-nitro-benzyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 49 percent / Et₃N / tetrahydrofuran / 3 h / Ambient temperature

2: K₂CO₃ / acetone / 5 h / Heating

3: ethanol. KOH / 2 h / Heating

4: (COCl)2, DMF / tetrahydrofuran; CH₂Cl₂ / 1 h / Ambient temperature

5: NaHCO₃ / H₂O; tetrahydrofuran; CH₂Cl₂ / 0.75 h

6: 2 M aq. HCl / dioxane / 36 h / Heating

With hydrogenchloride; potassium hydroxide; oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;
DOI:10.1021/ja00055a025