Technology Process of 3-((2S,3R)-2-Methoxy-tetrahydro-pyran-3-yl)-propan-1-ol
There total 2 articles about 3-((2S,3R)-2-Methoxy-tetrahydro-pyran-3-yl)-propan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / hydrogen bromide / pentane / Irradiation
2: 93 percent / triethylamine / CH2Cl2 / 3 h / Ambient temperature
3: 49 percent / hexamethylphosphoric acid triamide / 2 h / 60 °C
4: 88 percent / diisobutylaluminium hydride / hexane; tetrahydrofuran / 2 h / -78 °C
5: p-toluenesulfonic acid / 12 h / Ambient temperature
6: potassium carbonate, methanol / 6 h / Ambient temperature
With
methanol; hydrogen bromide; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; pentane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / hydrogen bromide / pentane / Irradiation
2: 93 percent / triethylamine / CH2Cl2 / 3 h / Ambient temperature
3: 49 percent / hexamethylphosphoric acid triamide / 2 h / 60 °C
4: 88 percent / diisobutylaluminium hydride / hexane; tetrahydrofuran / 2 h / -78 °C
5: p-toluenesulfonic acid / 12 h / Ambient temperature
6: potassium carbonate, methanol / 6 h / Ambient temperature
With
methanol; hydrogen bromide; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; pentane;
