5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene

Base Information

• Chemical Name: 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene
• CAS No.: 188651-21-0
• Molecular Formula: C₇₃H₆₅Br₄NO₁₇S₄
• Molecular Weight: 1676.2
• Mol file: 188651-21-0.mol

Synonyms:5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene

Chemical Property of 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene

There total 1 articles about 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

D-phenylglycine methyl ester hydrochloride (19883-41-1,13226-98-7) + 5,17-bis(carboxymethyl)-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene anhydride (188651-10-7) → 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene (188651-21-0)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Heating;

DOI:10.1021/jo962044p

Reference yield: 85.0%

(R)-Phenylglycine methyl ester (24461-61-8) + 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene (188651-21-0) → (R,R)-5,17-bis[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo962044p

Reference yield: 85.0%

(S)-Phenylglycine methyl ester (6591-61-3,24461-61-8,26682-99-5,37760-98-8) + 5-(carboxymethyl)-17-[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene (188651-21-0) → (R,S)-5,17-bis[({N-[(carbomethoxyphenyl)methyl]amino}carbonyl)methyl]-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo962044p

upstream raw materials:

D-phenylglycine methyl ester hydrochloride

5,17-bis(carboxymethyl)-11,23-di-tert-butyl-25,26,27,28-tetrakis[[(p-bromophenyl)sulfonyl]oxy]calix[4]arene anhydride