[(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Base Information

• Chemical Name: [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester
• CAS No.: 536739-11-4
• Molecular Formula: C₁₄H₁₆F₃O₄P
• Molecular Weight: 336.248
• Mol file: 536739-11-4.mol

Synonyms:[(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Chemical Property of [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester

There total 4 articles about [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(3-trifluoromethyl-benzyl)-phosphonic acid diallyl ester (536739-01-2) → [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester (536739-11-4)

Guidance literature:

With (-)-8,8-(dichlorocamphor)sulfonyloxaziridine; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00786-3

Reference yield:

O,O-Diethyl 3-Trifluoromethylphenylmethylphosphonate (146780-08-7) → [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester (536739-11-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 3 h / 0 °C

2: (COCl)2; DMF / CH₂Cl₂ / 1 h / 20 °C

3: 3.29 g / pyridine; DMAP / CH₂Cl₂ / -20 - 20 °C

4: 45 percent / NaHMDS; (-)-8,8-(dichlorocamphor)sulfonyloxaziridine / tetrahydrofuran / 3 h / -78 °C

With pyridine; dmap; oxalyl dichloride; (-)-8,8-(dichlorocamphor)sulfonyloxaziridine; sodium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(02)00786-3

Reference yield:

C8H6Cl2F3OP → [(R)-Hydroxy-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diallyl ester (536739-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.29 g / pyridine; DMAP / CH₂Cl₂ / -20 - 20 °C

2: 45 percent / NaHMDS; (-)-8,8-(dichlorocamphor)sulfonyloxaziridine / tetrahydrofuran / 3 h / -78 °C

With pyridine; dmap; (-)-8,8-(dichlorocamphor)sulfonyloxaziridine; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(02)00786-3

upstream raw materials:

(3-trifluoromethyl-benzyl)-phosphonic acid diallyl ester

O,O-Diethyl 3-Trifluoromethylphenylmethylphosphonate