(+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

Base Information

Chemical Name:(+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide
CAS No.:118920-28-8
Molecular Formula:C₂₆H₂₅NO₂
Molecular Weight:383.49
Hs Code.:

Synonyms:(+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

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Chemical Property of (+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

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Technology Process of (+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

There total 3 articles about (+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2627-86-3
(S)-1-phenyl-ethylamine

: C₁₈H₁₅ClO₂

: 118920-28-8
(+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

Guidance literature:: In dichloromethane; at -20 - 20 ℃; for 10h;
DOI:10.1021/jo00266a004

Reference yield:

: 118894-01-2
(+)-(1R,2R,5R)-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxylic acid

: 118920-28-8
(+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: DMF, oxalyl chloride / CH₂Cl₂ / 1 h / -20 °C

2: 75 percent / CH₂Cl₂ / 10 h / -20 - 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jo00266a004

Reference yield:

: 118894-00-1
methyl (+)-(1R,2R,5R)-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxylate

: 118920-28-8
(+)-(1R,2R,5R)-N-<(S)-1-phenylethyl>-2-methoxydibenzobicyclo<3.2.1>octadiene-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / potassium trimethylsilanolate / diethyl ether / 24 h / Ambient temperature

2: DMF, oxalyl chloride / CH₂Cl₂ / 1 h / -20 °C

3: 75 percent / CH₂Cl₂ / 10 h / -20 - 20 °C

With oxalyl dichloride; potassium trimethylsilonate; N,N-dimethyl-formamide; In diethyl ether; dichloromethane;
DOI:10.1021/jo00266a004