Aids005680

Base Information

Chemical Name:Aids005680
CAS No.:137530-41-7
Molecular Formula:C8H10FN3O3S
Molecular Weight:247.25
Hs Code.:
Mol file:137530-41-7.mol

Synonyms:4-Amino-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one;3-ethyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one;2',3'-dideoxy-3'-thia-5-fluorocytidine;3H-1,2,4-Triazol-3-one,4-amino-5-ethyl-2,4-dihydro;

Suppliers and Price of Aids005680

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ent-Emtricitabine
1mg
$ 460.00

TRC
ent-Emtricitabine
10mg
$ 1390.00

Crysdot
4-Amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one 95+%
1g
$ 592.00

Crysdot
4-Amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one 95+%
10g
$ 2666.00

Crysdot
4-Amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one 95+%
5g
$ 1777.00

Crysdot
4-Amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one 95+%
25g
$ 4800.00

Biosynth Carbosynth
(+)-Emtricitabine
25 mg
$ 3500.00

Biosynth Carbosynth
(+)-Emtricitabine
10 mg
$ 1560.00

Biosynth Carbosynth
(+)-Emtricitabine
5 mg
$ 825.00

Biosynth Carbosynth
(+)-Emtricitabine
2 mg
$ 370.00

Total 15 raw suppliers

Chemical Property of Aids005680

Chemical Property:

Melting Point:>80°C (dec.)
Boiling Point:443.3±55.0 °C(Predicted)
PKA:13.83±0.10(Predicted)
PSA：116.66000
Density:1.82±0.1 g/cm3(Predicted)
LogP:-0.11260
Storage Temp.:Hygroscopic, Refrigerator, Under inert atmosphere
Solubility.:DMSO (Sparingly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

ent-Emtricitabine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500). As a reverse transcriptase inhibitor, ent-EMtricitabine is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).

Technology Process of Aids005680

There total 5 articles about Aids005680 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.2%

: 144371-00-6,145213-48-5,145986-26-1
(+/-)-cis-2',3'-dideoxy-5-fluoro-3'-thiacytidine

: 137530-41-7,144371-00-6,145213-48-5,145986-26-1
racivir

Guidance literature:: With 1,1'-bi-2-naphthol; In methanol; Reflux;

Reference yield:

: N-[5-Fluoro-1-((2S,5R)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

: 137530-41-7,144371-00-6,145213-48-5,145986-26-1
racivir

Guidance literature:: With ammonia; In methanol; Yield given; Ambient temperature;
DOI:10.1021/jm00070a006

Reference yield:

: 149819-36-3
(+)-(2S,5R)-5-fluoro-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N₄-benzoylcytosine

: 137530-41-7,144371-00-6,145213-48-5,145986-26-1
racivir

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

2: NH₃ (gas) / methanol / Ambient temperature

With tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; methanol;
DOI:10.1021/jm00070a006