3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene

Base Information

• Chemical Name: 3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene
• CAS No.: 1607822-22-9
• Molecular Formula: C₁₂H₁₁F₃
• Molecular Weight: 212.215
• Mol file: 1607822-22-9.mol

Synonyms:3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene

Chemical Property of 3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene

Chemical Property:

Purity/Quality:

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Technology Process of 3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene

There total 1 articles about 3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

2-methyl-4-(4-(trifluoromethyl)phenyl)-3-butyn-2-ol → 3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene (1607822-22-9)

Guidance literature:

With tributylphosphine; In cyclohexane; at 100 ℃; for 24h;

DOI:10.1246/bcsj.20170372

Reference yield:

3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene (1607822-22-9) → C12H11F3

Guidance literature:

With gold(III) chloride; N-Phenylhydroxylamine; In acetonitrile; at 28 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo500009x

Reference yield:

3-methyl-1-{(4-trifluoromethyl)phenyl}-1,2-butadiene (1607822-22-9) → 4-methyl-2-phenyl-6-(4-(trifluoromethyl)phenyl)-3,6-dihydro-2H-1,2-oxazine (1607822-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: gold(III) chloride; N-Phenylhydroxylamine / acetonitrile / 48 h / 28 °C / Inert atmosphere

2: oxygen; copper dichloride / acetonitrile / 48 h / 28 °C

With gold(III) chloride; oxygen; N-Phenylhydroxylamine; copper dichloride; In acetonitrile;

DOI:10.1021/jo500009x

Downstream raw materials:

4-methyl-2-phenyl-6-(4-(trifluoromethyl)phenyl)-3,6-dihydro-2H-1,2-oxazine